IADR Abstract Archives
Photodynamic Therapy During Supportive Periodontal Therapy: A Randomised Split-mouth Controlled Trial
Objectives: The study aims to determine if application of photodynamic therapy (PDT), as an adjunct to scaling and root debridement, to residual pockets of patients undergoing supportive periodontal therapy (SPT) has added benefits.
Methods: 27 subjects on SPT, each with at least two residual pockets ≥5mm, were recruited for this randomised, split-mouth controlled trial, providing a total of 72 sites. At baseline, probing pocket depth (PPD), recession, clinical attachment level (CAL), plaque and bleeding on probing (BOP) of all sites were examined. Gingival crevicular fluid (GCF) were collected to determine level of IL-1β via ELISA. Control sites received subgingival instrumentation and rubber cup polishing with pumice. In addition test sites received a single application of PDT using Fotosan® and photosensitizer consisting of toludine blue O solution. The subjects were recalled three months later and re-examined. Site level analysis was performed.
Results: Based on mixed model analysis, test sites showed significant gain (p = 0.040) in CAL - from 6.14 (95% CI 5.67, 6.61)mm to 5.91 (95% CI 5.46, 6.36)mm at three months as compared to control sites - from 6.22 (95% CI 5.79, 6.65)mm to 6.29 (95% CI 5.84, 6.74)mm. There were no significant benefits for test sites in terms of PPD, recession, plaque and BOP. There was significant reduction in the level of IL-1β over three months - from 234.3 (95% CI 171.8, 296.9)pg/mL to 148.5 (95% CI 81.8, 21.52)pg/mL (p=0.240), with no significant differences between test and control sites.
Conclusions: A single application of PDT to residual pockets provided a modest gain of CAL over 3 months and can be recommended for patients on SPT.
Methods: 27 subjects on SPT, each with at least two residual pockets ≥5mm, were recruited for this randomised, split-mouth controlled trial, providing a total of 72 sites. At baseline, probing pocket depth (PPD), recession, clinical attachment level (CAL), plaque and bleeding on probing (BOP) of all sites were examined. Gingival crevicular fluid (GCF) were collected to determine level of IL-1β via ELISA. Control sites received subgingival instrumentation and rubber cup polishing with pumice. In addition test sites received a single application of PDT using Fotosan® and photosensitizer consisting of toludine blue O solution. The subjects were recalled three months later and re-examined. Site level analysis was performed.
Results: Based on mixed model analysis, test sites showed significant gain (p = 0.040) in CAL - from 6.14 (95% CI 5.67, 6.61)mm to 5.91 (95% CI 5.46, 6.36)mm at three months as compared to control sites - from 6.22 (95% CI 5.79, 6.65)mm to 6.29 (95% CI 5.84, 6.74)mm. There were no significant benefits for test sites in terms of PPD, recession, plaque and BOP. There was significant reduction in the level of IL-1β over three months - from 234.3 (95% CI 171.8, 296.9)pg/mL to 148.5 (95% CI 81.8, 21.52)pg/mL (p=0.240), with no significant differences between test and control sites.
Conclusions: A single application of PDT to residual pockets provided a modest gain of CAL over 3 months and can be recommended for patients on SPT.