Wear potential of dental materials and wear on natural dentition is critical when selecting restorative materials. Objective: To determine the wear characteristics of different acrylic/resin denture teeth when opposed by porcelain ceramic. Methods: An automated in vitro wear device (Vitrowear apparatus) was fitted with different acrylic/resin denture teeth (1 X molar and 1 X premolar of: Dentron, Senator, Status, Orthoplane, Orthosit, Vitapan, Wiedent, Yamahachi). Ceramco porcelain blocks opposed these teeth and accelerated wear was induced over 6000, 12000 and 18000 wear cycles with a total preload of 2.1kg. The environmental temperature was regulated at 37.5°C and all samples were irrigated with deionised water to assure a two-body wear. Before wear the offset of selected points (at the cusp tips) from the mounting ring of the sample were determined (data before wear) with a Reflex microscope. The off set of the same selected points was measured after the different wear cycles and the loss of tooth structure was calculated. Results: Total wear over 6000, 12000 and 18000 cycles indicated that the least amount of wear was on the Senator group (0.0146 ± 0.0106mm) and the highest amount of wear was on the Orthosit group (0.4043 ± 0.1627mm) (P<0.05). Wear on the other samples varied between 0.0451 ± 0.0153mm (Dentron) and 0.1702 ± 0.0638mm (Status) after 6000 cycles and 0.1313 ± 0705mm (Orthoplane) and 0.2713 ± 0.0987mm (Status) after 18000 cycles. Although wear variation in these groups was statistically significant (P<0.05) the clinical significance is not established. Conclusion: Wear measurement indicated that the acryl/resin dentures most resistant to wear by porcelain is the Senator group of denture teeth, whilst the Orthosit group is the least resistant to wear by porcelain.