There are a lack of studies about clinical performance of minimally invasive treatments, chemo-mechanical method and Atraumatic Restorative Treatment. Objective: To evaluate the clinical performance of high strength glass ionomer cement restorations comparing two minimally invasive methods in permanent teeth after 12 months. Methods: A total of 50 pregnant women (second trimester of pregnancy), mean age 22±5.30 years, were treated by two operators. The treatment approaches tested were: CM method (
CarisolvTM- MediTeam, Sweden) and ART. A split-mouth study design was used in which the two treatments were randomly placed in 50 matched pairs of permanent teeth. The CM method was used as test group and the ART as control group. The restorations (Ketac Molar, 3M ESPE) were placed according to ART guidelines. Two calibrated independent examiners evaluated the restorations in accordance with ART criteria. The inter examiner kappa was 0.97. The data were analyzed using 95% confidence interval on the binomial distribution and Fisher Exact test. Results: In a 12-month follow-up, 86% of the restorations were evaluated. In the test group (CM) 100% (CI=93.3-100%) of the restorations were considered successful. In the control group (ART) 97.6% (CI=87.4-99.9%) of the restorations were considered successful and 2.4% unsuccessful (marginal defect >0.5 mm). There was no statistically significant difference (p<0.05) between the 12-mounth success rate for both groups (Fisher test: P=0.49), and between the two operators (Fisher test: P=1.00). The two minimal interventional approaches, chemo-mechanical method and ART, showed similar clinical performance after 12 months. kmodena@usp.br