IADR Abstract Archives
Hypothyroidism, Autoimmunity and Systemic Characteristics of Salivary Tumors
Objectives: We wished to examine demographic, ethnic, and systemic characteristics of patients diagnosed with salivary benign and malignant tumors in order to better understand possible etiological roles.
Methods: Medical records of 287 patients who received definitive treatment for primary salivary glands tumors in Rambam Medical Center, Haifa, Israel, were examined.
Results: . Of 287 cases, 214 had benign tumors and 73 malignant tumors. Mean age at diagnosis in the malignant group was 56.4 years (median 57.0) and 48.5 years (median 51.0) in the benign group, a highly significant difference (p=0.001). As for gender, females represented 45% of patients in the malignant group and 59% in the benign group, significant difference (p=0.037). The baseline variables of ethnic origin, alcohol consumption and cigarette smoking rates were not significantly different (p>0.05) between the groups. While the prevalence rates of patients with diabetes mellitus (DM), cerebro-vascular attack (CVA) and/or ischemic heart disease (IHD), hypertension (HTN) and hyperlipidemia (HL) between the two study groups were not significantly different (p>0.05), the percent of patients with hypothyroidism (10.2%) in the benign group was significantly higher than in the malignant group (1.4%), (p=0.021).
Conclusions: The obtained results are discussed with respect to the available literature and seem to support the notion that autoimmunity may play a significant etiological role in benign but not malignant salivary tumors, further supported by the significantly higher prevalence of women in the benign group.
Methods: Medical records of 287 patients who received definitive treatment for primary salivary glands tumors in Rambam Medical Center, Haifa, Israel, were examined.
Results: . Of 287 cases, 214 had benign tumors and 73 malignant tumors. Mean age at diagnosis in the malignant group was 56.4 years (median 57.0) and 48.5 years (median 51.0) in the benign group, a highly significant difference (p=0.001). As for gender, females represented 45% of patients in the malignant group and 59% in the benign group, significant difference (p=0.037). The baseline variables of ethnic origin, alcohol consumption and cigarette smoking rates were not significantly different (p>0.05) between the groups. While the prevalence rates of patients with diabetes mellitus (DM), cerebro-vascular attack (CVA) and/or ischemic heart disease (IHD), hypertension (HTN) and hyperlipidemia (HL) between the two study groups were not significantly different (p>0.05), the percent of patients with hypothyroidism (10.2%) in the benign group was significantly higher than in the malignant group (1.4%), (p=0.021).
Conclusions: The obtained results are discussed with respect to the available literature and seem to support the notion that autoimmunity may play a significant etiological role in benign but not malignant salivary tumors, further supported by the significantly higher prevalence of women in the benign group.