IADR Abstract Archives

Platelet concentrates benefit on sinus lifting: a systematic review

Objective:   There is a great interest regarding the use of platelet concentrates such as platelet–rich plasma (PRP) or platelet rich fibrin (PRF) alone or in conjunction with autografts or bone graft substitutes in sinus lift procedures. However, the benefits are still unclear. The aim of this review was to analyse clinical studies in order to evaluate whether PRP or PRF has a positive adjunctive effect on new bone formation and/or implant survival when used in combination with autografts or bone graft substitutes.

Methods: A Medline and Embasy and Cochrane search was conducted considering the literature from 1998 to 2013. Non-English manuscripts and articles on nonhuman subjects as well as studies with an improper study design, case series, and technical report were excluded. Systematic review and all controlled trials involving use of either PRP or PRF in combination with autogenous bone or bone substitute, in sinus augmentation procedures for implant insertion, were included. Outcome measures were histomorphometric parameters evaluating new bone formation and/or implant survival.

Results: Literature analysis showed 2 systematic reviews, 9 controlled trials and 12 randomized controlled trials that fulfilled the inclusion criteria: 2 CCT et 6 RCT papers on PRP with autografts, 1 CCT on PRP with bone substitut (BioOss® ) et 6 RCT (1 FDBA, 1 Β-TCP, and 4 BioOss®) and 3 CCT on PRF with bone substitute (1 FDBA and 2 BioOss®) were identified. Methods of quantifying new bone formation PRP preparation and time of healing differ between studies. Data regarding PRP use in combination with autografts or bone graft substitutes showed conflicting data. Regarding PRF, few non-randomized trials were identified.

Conclusion:   Scientific evidence of the PRP and or PRF benefit when used in combination with autografts or bone graft substitutes in sinus augmentation is still limited.

 

Pan European Region Meeting
2014 Pan European Region Meeting (Dubrovnik, Croatia)
Dubrovnik, Croatia
2014
154
Scientific Groups
  • Bouzegza, Salim  ( Hôpital Pitié Salpêtrère, Paris, , France )
  • Chemlal, Moulay  ( Hôpital Pitié Salpêtrière, Paris, , France )
  • Moussali, Riad  ( Hôpital Pitié Salpêtrière, PAris, , France )
  • Cohen, Nicolas  ( Hôpital Pitié Salpetrière, Paris, , France )
  • Anagnostou, Fani  ( Paris 7 University, Paris, , France ;  Laboratoire de BioIngenierie et Bioimagérie Ostéo-articulaires, Paris, , France ;  Pitié Salpétrière Hospital, Paris, , France )
    • Poster Session
    Oral and Maxillofacial Surgery II
    09/11/2014