Method: A systematic review of published and unpublished case control and cohort studies was undertaken which presented data relating to oral health and oral cancer risk. Studies were included which reported odds ratios (ORs) and corresponding 95% confidence intervals (CIs) of oral cancer with respect to oral health, or if the estimates could be calculated or obtained. Ovid Medline, Embase and Web of Science databases were searched, reference lists were examined and contact with experts in the field was undertaken. Each study was assessed regarding the methodological quality including adjustment for known confounding factors.
Result: Twenty-four studies were identified which met our inclusion criteria. The oral health factors identified and the number of studies that correspond are as follows: tooth brushing frequency - 5, oral hygiene - 3, denture wear - 10, dental attendance - 8, missing teeth - 7, bleeding gums - 6, general oral health - 4, and broken teeth - 3.
Conclusion: From the current evidence available, there appears to be a link between oral health and oral cancer risk.