To evaluate the efficacy of topical Hyaluronic Acid 0.2% in reducing ulcer size and pain of minor recurrent aphthous ulceration.
Method:
A controlled clinical trial was performed. 40 patients with minor aphthous ulcers were included in the study (20 patients was treated with topical hyaluronic acid 0.2%, and 20 patients received no treatment). The
level of pain and maximum diameter of ulcers were measured and recorded on days 0, 2 and 5.
Result:
Hyaluronic acid significantly relieved ulcer pain (P<0.05) for days 2 and 5, and reduced the maximum diameter of ulcers (P<0.05) for days 2 and 5.
By the day 5of treatment, 30% of the ulcers had clinically healed in the study group, compared to 5% in the control group.
Conclusion:
Topical Hyaluronic acid 0.2% (GENGIGEL®) is an effective therapy for reducing the ulcer size and relieving pain of minor recurrent aphthous ulcers.