IADR Abstract Archives
Is Cross-Linked Hyaluronic Acid a Successful Molecule for a Successful GBR?
Abstract Body: Hyaluronic acid (HyA), an anionic, non-sulfated glycosaminoglycan structured biomolecule, is a major natural component of the extracellular matrix in many tissues including the skin, joints, eyes, and periodontium. Physiochemically and biologically, HyA is hygroscopic, viscoelastic, bacteriostatic, antibacterial, anti-inflammatory, and anti-edematous. It significantly stimulates clot formation, induces angiogenesis, and increases osteogenesis.
A novel high molecular, cross-linked formulation (xHyA) has recently been shown to enhance the proliferative, migratory and wound healing properties of cell types involved in soft tissue wound healing following regenerative periodontal surgery, induces the growth of osteoprogenitors and maintains their stemness, thus potentially regulating the balance between self-renewal and differentiation during bone regeneration following reconstructive oral surgeries.
The aim of the present symposium is to summarize, in three consecutive lectures, the current biologic and clinical evidence on the use of xHyA in various oral reconstructive surgical procedures.
The available evidence from preclinical and clinical studies indicates that :
xHyA promotes periodontal wound healing/regeneration in intrabony-, recession and furcation defects and improves the outcomes of regenerative surgery in intrabony defects and recession coverage procedures.
The combination of xHyA with various types of bone grafting materials may additionally improve the outcomes of regenerative periodontal surgery in complex clinical scenarios.
Very recent clinical observations have also pointed to the potential clinical benefit of using xHyA in Guided Bone Regeneration (GBR).
A novel high molecular, cross-linked formulation (xHyA) has recently been shown to enhance the proliferative, migratory and wound healing properties of cell types involved in soft tissue wound healing following regenerative periodontal surgery, induces the growth of osteoprogenitors and maintains their stemness, thus potentially regulating the balance between self-renewal and differentiation during bone regeneration following reconstructive oral surgeries.
The aim of the present symposium is to summarize, in three consecutive lectures, the current biologic and clinical evidence on the use of xHyA in various oral reconstructive surgical procedures.
The available evidence from preclinical and clinical studies indicates that :
xHyA promotes periodontal wound healing/regeneration in intrabony-, recession and furcation defects and improves the outcomes of regenerative surgery in intrabony defects and recession coverage procedures.
The combination of xHyA with various types of bone grafting materials may additionally improve the outcomes of regenerative periodontal surgery in complex clinical scenarios.
Very recent clinical observations have also pointed to the potential clinical benefit of using xHyA in Guided Bone Regeneration (GBR).