IADR Abstract Archives
Cell-Homing Versus Cell-Transplantation Approach for Dental-Pulp Regeneration: a Systematic Review
Objectives: The main objective of this systematic review was to compare the apical healing, root maturation and histological characteristics of teeth treated with the cell-based versus the cell-free techniques.
Methods: A literature search strategy was carried out on PubMed, EMBASE and the Web of Science databases. The last search was done on 1 August 2021. No filters or language restrictions were initially applied. Two researchers independently selected the studies and extracted the data. As randomized clinical trials were not available, animal studies were included.
Results: In total, 26 studies were included in the systematic review. In terms of apical healing, the qualitative analysis of the data suggested that there seems to be no significant difference between the cell-free and the cell-based techniques. The results regarding root maturation of immature teeth are contradictory. Two articles concluded that the cell-based technique results in significantly more apical closure than the cell-free technique whilst another article concluded that there was no significant significant difference between both techniques regarding root maturation. The main difference between the cell-free and the cell-based techniques seems to be the histology of the treated tooth. The cell-free technique seems to result in cementum-like, bone-like or periodontal ligament-like tissue. One study, on the other hand, found that the cell-based technique resulted in regeneration of the whole pulp with an odontoblast layer, connective tissue, blood vessels and neuronal tissue.
Conclusions: Currently, the amount of randomized clinical trials on this topic are very scarce. This is probably due to the limited infrastructure and lack of resources to apply the cell-basd technique. Even though both techniques seem to be promising for clinical application, long-term data needs to be provided regarding the healing and reparative patterns after regenerative endodontic therapy.
Methods: A literature search strategy was carried out on PubMed, EMBASE and the Web of Science databases. The last search was done on 1 August 2021. No filters or language restrictions were initially applied. Two researchers independently selected the studies and extracted the data. As randomized clinical trials were not available, animal studies were included.
Results: In total, 26 studies were included in the systematic review. In terms of apical healing, the qualitative analysis of the data suggested that there seems to be no significant difference between the cell-free and the cell-based techniques. The results regarding root maturation of immature teeth are contradictory. Two articles concluded that the cell-based technique results in significantly more apical closure than the cell-free technique whilst another article concluded that there was no significant significant difference between both techniques regarding root maturation. The main difference between the cell-free and the cell-based techniques seems to be the histology of the treated tooth. The cell-free technique seems to result in cementum-like, bone-like or periodontal ligament-like tissue. One study, on the other hand, found that the cell-based technique resulted in regeneration of the whole pulp with an odontoblast layer, connective tissue, blood vessels and neuronal tissue.
Conclusions: Currently, the amount of randomized clinical trials on this topic are very scarce. This is probably due to the limited infrastructure and lack of resources to apply the cell-basd technique. Even though both techniques seem to be promising for clinical application, long-term data needs to be provided regarding the healing and reparative patterns after regenerative endodontic therapy.