IADR Abstract Archives

Osteoprotegerin levels in Gingival Crevicular Fluid during Orthodontic Tooth Movement

Objectives: Orthodontic teeth movement through bone occurs during the bone remodeling process that is induced by the therapeutic mechanical forces. Bone is resorbed by osteoclasts in pressure areas which the force is directed and deposited at tensile areas. Osteoprotegerin was shown to inhibit osteoclastogenesis and also diminished orthodontic tooth movement was reported after induction of osteoprotegerin release from periodontium. The purpose of this study was to evaluate the levels of osteoprotegerin during mechanically induced orthodontic tooth movement and to evaluate the effect of orthodontic forces on periodontal tissues at tension and pressure sites.

Methods: Eighteen canine teeth of eight adolescent patients with different Angle classifications were selected. After extraction of first premolars retraction forces were applied to canine teeth at distal direction. For this purpose sentalloy closed coil springs with eyelets generating forces of 150 grams were used. The forces were verified by a calibrated force gauge. Gingival crevicular fluid was sampled from each mesial and distal site at baseline and 1, 24 hours, 7 and 30 days after force. An enzyme-linked immunosorbent assay for quantitative detection of osteoprotegerin was used. Repeated measurement ANOVA was used for statistical analysis of the data.

Results: No statistically significant difference was detected at intra-group or inter-group data analysis for total amounts and concentrations of osteoprotegerin in gingival crevicular fluid.

Conclusion: These results suggest that osteoprotegerin in the gingival crevicular fluid does not appear to be the important determinant regulating the balanced alveolar bone resorption during the orthodontic tooth movement.


Pan European Federation Meeting
2008 Pan European Federation Meeting (London, England)
London, England
2008
542
PEF IADR 2008
  • Özdemir, Burcu  ( Gazi University Faculty of Dentistry Department of Periodontology, Ankara, N/A, Turkey )
  • Balos Tuncer, Burcu  ( Gazi University Faculty of Dentistry Department of Orthodontics, Ankara, N/A, Turkey )
  • Atak, Aysegül.  ( Gazi University School of Medicine Department of Immunology, Ankara, N/A, Turkey )
  • Boynuegri, Duygu  ( Gazi University Faculty of Dentistry Department of Periodontology, Ankara, N/A, Turkey )
  • Bavbek Karakaya, Idil  ( Gazi University Faculty of Dentistry Department of Orthodontics, Ankara, N/A, Turkey )
  • Balos, K.öksal  ( Gazi University Faculty of Dentistry Department of Periodontology, Ankara, N/A, Turkey )
  • Aral, Latife Arzu  ( Gazi University School of Medicine Department of Immunology, Ankara, N/A, Turkey )
  • Özmeriç, Nurdan  ( Gazi University Faculty of Dentistry Department of Periodontology, Ankara, N/A, Turkey )
    • Poster Session
    Periodontal Research: Pathogenesis
    09/11/2008