Allomatrix Injectable Putty for the Treatment of Generalized Aggressive Periodontitis

Objectives: The combination of human demineralized bone matrix with a synthetic calcium sulfate has been recently introduced as a treatment modality for predictably obtaining periodontal regeneration. To date, there is insufficient data regarding the use of this combination in the treatment of generalized aggressive periodontitis (GAP) patients who are difficult to manage clinically. The present study aims to assess the clinical and radiographic effect of this combination (Allomatrix Injectable Putty) in the treatment of the patients with GAP. Methods: Twelve GAP patients who received non-surgical periodontal therapy were included. A total of 39 intrabony defects with an associated probing depth (PD) of > 6 mm and an intrabony component of > 3 mm were surgically treated with Allomatrix Injectable Putty. Prior to surgical treatment and at 8 months, plaque and sulcus bleeding indices, PD, marginal soft tissue and relative attachment levels, probing bone and radiographic bone levels were measured. Results: Healing was uneventful in all patients. At 8 months postoperatively, favorable clinical outcomes in soft and hard tissue measurements were achieved when compared to baseline (p<0.05). Considering the deepest site of the defects, 3.24±0.26 mm of PD reduction, 2.70±0.37 mm of attachment gain, 0.70±0.37 mm of recession, were obtained. The mean clinical and radiographic bone gain was 2.48±0.32 mm and 2.67±0.86 mm, respectively. Conclusions: Within the limits of this study, it was concluded that Allomatrix Injectable Putty is promising for clinical and radiographic improvements in the treatment of GAP.