IADR Abstract Archives

Platelet-Rich Plasma and Bovine Derived Xenograft Combination in Intrabony Defects

Objectives: The use of polypeptide growth factors (PGFs) for periodontal regeneration has recently attracted the attention of periodontal researchers. A convenient approach to obtain autologous PGFs is the use of platelet-rich plasma (PRP). There is currently great interest concerning the use of PRP in combination with bone graft materials as a treatment modality for predictably obtaining periodontal regeneration through bioengineering. The aim of the present study was to investigate the effectiveness of a regenerative procedure based on combined PRP and bovine derived xenograft (BDX) application in the treatment of deep intrabony periodontal defects. Methods: Twelve advanced chronic periodontitis patients, seven females and five males, aged 32–59 years, were included. A total of 47 intrabony defects with an associated probing depth (PD) of >6 mm and an intrabony component of > 3 mm were selected. Defects were surgically treated with PRP/BDX. At baseline and 8 months after surgery, the following clinical and radiographical parameters were recorded: plaque and sulcus bleeding indices, PD, marginal soft tissue and relative attachment levels, probing bone and radiographical bone levels. Results: No adverse event related to the use of PRP was noted. At 8 months postoperatively, clinical and radiographical parameters were improved when compared to baseline (p<0.05). The mean changes at 8 months at the deepest sites were: PD reduction of 4.61±1.25 mm, recession of 0.78±0.34 mm, attachment gain of 3.76±0.92 mm, clinical bone gain of 3.49±0.76 mm, and radiographic bone gain of 3.83±1.17 mm, respectively. Conclusions: Treatment with a combination of PRP and BDX leads to a significantly favorable clinical and radiographical improvement in deep intrabony periodontal defects. Further randomized controlled studies are needed to clarify the role played by each component of the combined therapy.


Pan European Federation Meeting
2006 Pan European Federation Meeting (Dublin, Ireland)
Dublin, Ireland
2006
149
Scientific Groups
  • Yildirim, Burak  ( Yeditepe University, Istanbul, N/A, Turkey )
  • Yilmaz, Selcuk  ( Yeditepe University, Istanbul, N/A, Turkey )
  • Cakar, Gokser  ( Yeditepe University, Istanbul, N/A, Turkey )
  • Poster Session
    H. Periodontal Research, Poster Session I
    09/13/2006