Case-control study of the anovulistatics influence in saliva composition

Objectives: To evaluate if consumption of anovulistatics has an influence in the calcium levels, inorganic phosphate and sialic acid in saliva. Introduction: Calcium takes part in the dental mineralizing, phosphates are even used like anticariogenics and sialic acid contributes to the viscosity of the saliva being associated to the mucosa protection and minor rates of dry mouth. Methods: A random sample has been taken of 94 women: average age 32±3,8 that have been consuming steroid anovulistatics during more than 5 years and 88 women of average age 34,3±3,2 that have not been consuming steroid anovulistatics during more than the last 2 years. Saliva samples had been collected using paraffin stimulation and sialic acid, inorganic phosphates and calcium was determined using spectrophotometry and atomic absorption spectrophotometry. Results: Calcium, in nonconsuming 1,26±0,2mmol/l; consumers 1,12±0,2mmol/l ;Inorganic phosphate, in nonconsuming 4,73±1,2 mmol/l; consumers 4,72±1,12mol/l; siálic acid, nonconsuming 32,1±8,6mmol/l; consumers 28,1±7,3mmol/l. Flow rate (ml/min), nonconsuming 1,42±0,42ml/min; consumers 1,53±0,51 ml/min. Discussion: The results show that the rates of calcium and siálico acid are lower in in the group who ingest steroids. There were more men with high level p= 0,045. Subjects with high levels has lower DMF p= 0,045. This is associated to that the steroids restrict the loss of calcium in the bones. The inferior levels of sialic acid could be related to the increase of salivary flow caused by steroids. Conclusion: There are inferior rates of calcium and sialic acid in the group that ingests steroids but greater rates of salivary flow.