IADR Abstract Archives

Periodontal Tissue Regeneration: A Model for Drug Delivery Studies

Introduction: Periodontal disease is a common cause of tooth loss in adults due to the destruction of bone and connective tissues. Currently available treatments are based on surgical approaches such as access flap or guided tissue regeneration. These are effective in some cases, although evidence for substantial bone regeneration is limited. Bioactive materials including bioglasses, bioglass-ceramics, and calcium phosphate ceramics have been reported for the reconstruction of bones tissues. While in vivo data is promising, this is not always reflected in real clinical practise.

Objective: The aim of the present study was to design a model periodontal bone defect, and to investigate dye release from particulate bioglass to mimic drug elution.

Methods: Models of periodontal bone defects for investigation of drug delivery have not been reported to date. We designed a model of a bone defect 3 mm in depth and 4 mm diameter using cylindrical acrylic moulds based on data from published clinical studies. In vitro drug release from 45S5 bioglass was investigated using methylene blue dye. 45S5 bioglass was melt derived, milled and sieved to obtain particle sizes of 150-425 mm.This is similar to the range of sizes in commercial Perioglass®.The composition was confirmed using X-ray fluorescence spectroscopy (XRF) and the detailed morphology was characterised by scanning electron microscopy (SEM).

Result: Dye release from the bioglass was greatest at early time points, indicating that a ²surface burst² occurred before sustained release of much lower level but very slow levels of dye released.

Conclusion: We concluded that the model reported here has some value for periodontal drug release studies, and it is therefore a significant advance on current approaches based on simple elution from a disc or tablet.


Pan European Federation Meeting
2006 Pan European Federation Meeting (Dublin, Ireland)
Dublin, Ireland
2006
150
Scientific Groups
  • Mirvakily, Felora  ( University of Sheffield, Sheffield, N/A, United Kingdom )
  • Rawlinson, A.  ( University of Sheffield, Sheffield, N/A, United Kingdom )
  • Hatton, P.v.  ( University of Sheffield, Sheffield, N/A, United Kingdom )
  • Hurrell-gillingham, K.  ( University of Sheffield, Sheffield, N/A, United Kingdom )
    • Poster Session
    H. Periodontal Research, Poster Session I
    09/13/2006