IADR Abstract Archives

Chlorhexidine Efficacy in Preventing Lesion Formation in Dentin and Enamel

Objective: The aim of this study was to evaluate the effect of 0.2% chlorhexidine (Corsodyl®) mouthrinse on lesion formation in dentin and enamel placed in situ.

Methods: 14 volunteers, wearing a partial prosthesis, participated in this randomized crossover study. A sound dentin and enamel specimen covered with Dacron® gauze were mounted in the buccal flanges. During the first leg of 4 weeks, the participants were asked to perform a mouthrinse with either 10 mL 0.2% chlorhexidine or saline (0.9% NaCl) for 60 sec twice daily. After a 2-week washout period an identical rinsing procedure was followed using the alternative mouthrinse. During the experimental period, non-fluoridated toothpaste was used. After retrieving the dentin and enamel specimens, lesion formation and mineral loss were determined using transversal microradiography.

Results:

 

 

Dentin (n=13)

 

Control

 

Chlorhexidine

   
 

Range

Median

 

Range

Median

 

p valueb

IMLa (vol%.µm)

448.0 - 20498.9

6930.6

 

171.2 - 17229.1

6229.6

 

0.46

               

Lesion depth (µm)

70.1 - 584.9

337.1

 

29.5 - 554.7

276.6

 

0.20

               
  Enamel (n=14)
 

Control

 

Chlorhexidine

   
 

Range

Median

 

Range

Median

 

p valueb

IMLa (vol%.µm)

83.3 - 12661.3

4660.3

 

48.4 - 12308.4

2393.5

 

0.36

               

Lesion depth (µm)

3.7 - 356.3

169.1

 

2.6 - 267.1

102.6

 

0.06

               

a Integrated mineral loss

           

b p value Wilcoxon signed rank test (2-tailed)

         
 

 

Conclusion: This experiment could not demonstrate a significant better protection of dentin and enamel against demineralization by chlorhexidine compared to saline.

 


Pan European Federation Meeting
2006 Pan European Federation Meeting (Dublin, Ireland)
Dublin, Ireland
2006
380
Scientific Groups
  • Van Strijp, A.j.p.  ( Academic Centre for Dentistry Amsterdam (ACTA), Amsterdam, N/A, Netherlands )
  • Gerardu, V.a.m.  ( Academic Centre for Dentistry Amsterdam (ACTA), Amsterdam, N/A, Netherlands )
  • Buijs, M.j.  ( Academic Centre for Dentistry Amsterdam (ACTA), Amsterdam, N/A, Netherlands )
  • Van Loveren, C.  ( Academic Centre for Dentistry Amsterdam (ACTA), Amsterdam, N/A, Netherlands )
  • Ten Cate, J.m.  ( Academic Centre for Dentistry Amsterdam (ACTA), Amsterdam, N/A, Netherlands )
  • Poster Session
    D. Cariology Poster Session II
    09/14/2006