Amyloidosis of the palate - Concise Report

Methods: To report a rare cause of amlyoidosis of the palate

Results: Biopsy results confirmed the deposition of amyloid in the palate. The lesion on the palate was extensive and complete excision of the lesion and healing by secondary intention was not a valid treatment option due to the size of the palatal lesion. After discussion with the patient and relatives this lady was managed conservatively bearing in mind her age and possible co morbidity following treatment which would have involved a general anaesthetic. Yearly CT scans showed that the palate and maxillary sinuses remained intact. The palatal lesion did not appear to have extended in size and the patient responded being well and able to wear her upper denture.

Conclusions: Solitary oral manifestations of generalised amyloid are not uncommon and amyloid can be deposited in the buccal mucosa, palate, tongue and gingival. There are few reports in the literature of isolated intra-oral amyloid in sites other than the tongue or gingivae. Primary amyloid of the palate is rare. There appears to be only four other reports in the literature. Localised amyloidosis does not appear to progress to systemic disease but there is no consensus as to the best form of management. Surgical excision may be indicated, particularly if the patient reports discomfort or the lesion is spreading and/or involving the regions surrounding the palate. Solitary lesions of amyloidosis can however recur and following excision and patients should be warned that surgery may be palliative, rather than curative