Materials and methods: S. mutans ATCC 25175 was treated with various concentrations of aluminium potassium sulfate. The growth, lactic acid production, bacterial adhesion and water-insoluble glucan synthesis were also investigated. The data were collected and presented in form of mean ± standard deviation values and analyzed by SPSS Version15. Each study was performed at least three separate independent experiments.
Results: The minimum inhibitory concentration (MIC) and the minimum bactericidal concentration (MBC) of aluminium potassium sulfate against S. mutans were 0.5 and 3 mM, respectively. Below the MBC, aluminium potassium sulfate significantly reduced the rate of lactic acid production, adhesion to saliva-coated hydroxyapatite and water-insoluble glucan synthesis of S. mutans in dose-dependent manner.
Conclusion: Aluminium potassium sulfate is efficient to attenuate bacterial growth, lactic acid production, adhesion to saliva-coated hydroxyapatite beads and water-insoluble glucan synthesis of S. mutans, in vitro.