Antibody levels to Porphyromonas gingivalis and CRP in periodontitis patients
Objectives: An elevation of high-sensitivity C-reactive protein (hs-CRP) by periodontal infection may account for an increased risk of developing coronary heart disease (CHD). In addition, several reports have demonstrated a possible association of periodontal infections with CHD by elevated antibody titer to periodontopathic bacteria in CHD patients compared with non-diseased controls. However, relationship between antibody levels which indicate robustness of infection and hs-CRP levels indicating systemic inflammatory status has not been examined. In this study, we attempted to elucidate the relationship between antibody levels to Porphyromonas gingivalis (P. gingivalis) and serum hs-CRP levels in Japanese periodontitis patients.
Methods: Sera were obtained at baseline examination and at least 6 weeks after the completion of active therapy from 68 patients with moderate to severe periodontitis. Serum levels of antibody to P. gingivalis strains FDC381 and SU63 were measured by ELISA and hs-CRP level was measured with nephelometry, a latex particle-enhanced immunoassay. Forty non-diseased subjects served as a control.
Results: Antibody levels to both strains elevated with increasing severity of the disease at baseline and decreased after successful treatment. Although hs-CRP level was significantly higher in periodontitis patients compared with non-diseased controls, the hs-CRP levels positively correlated with neither clinical profiles nor antibody levels in periodontitis patients. However, if the hs-CRP levels were dichotomized at a level of 1mg/L that is reported to be cut-off point for high-risk of future development of CHD in Japanese, the antibody level was higher in patients with hs-CRP of > 1mg/L compared with those with serum hs-CRP of ≤ 1mg/L.
Conclusion: These results not only provide further support for periodontitis as a risk factor for CHD but also suggest that the measurement of antibody levels to P. gingivalis in combination with hs-CRP may be a good predictor of future development of CHD. Supported by JSPS grant (19390536).
Division: Asia/Pacific Region Meeting
Meeting:2009 Asia/Pacific Region Meeting (Wuhan, China) Location: Wuhan, China
Year: 2009 Final Presentation ID:657 Abstract Category|Abstract Category(s):Scientific Groups
Authors
Miyashita, Hirotaka
( Center for Transdisciplinary Research, Niigata University, Niigata, N/A, Japan
)
Honda, Tomoyuki
( Center for Transdisciplinary Research, Niigata University, Niigata, N/A, Japan
)
Okui, Takafumi
( Center for Transdisciplinary Research, Niigata University, Niigata, N/A, Japan
)
Maekawa, Tomoki
( Center for Transdisciplinary Research, Niigata University, Niigata, N/A, Japan
)
Takahashi, Naoki
( Center for Transdisciplinary Research, Niigata University, Niigata, N/A, Japan
)
Ito, Harue
( Center for Transdisciplinary Research, Niigata University, Niigata, N/A, Japan
)
Nakajima, Takako
( Center for Transdisciplinary Research, Niigata University, Niigata, N/A, Japan
)
Tabeta, Koichi
( Center for Transdisciplinary Research, Niigata University, Niigata, N/A, Japan
)
Yamazaki, Kazuhisa
( Center for Transdisciplinary Research, Niigata University, Niigata, N/A, Japan
)