Objective: It is now becoming widely recognized that certain oral disease may increase the risk for various systemic diseases. Less attention had been paid in exploring the role that chronic oral infections (COIs) may have on systemic health especially in the developing countries like Pakistan. There is increasing evidence that relationship between chronic oral disease and cardiovascular diseases such as coronary artery disease (CADs).The current study was designed to investigate the status of oral health in CAD patients and evaluate any relationship between COIs and CADs Materials & Methods: This case control study was conducted in Shaikh Zayed Medical Complex, Lahore, Pakistan (SZMC) on 290 patients. The study subjects in the category of Cases (patients suffering from CAD) were recruited from the cardiology wards of the SZMC, Lahore, Pakistan. Controls were taken as either the attendants of these patients having no previous history of coronary artery disease or the patients attending any other OPD of SZM. Results: After matching both the cases and controls completely in terms of age, sex, educational status and socioeconomic status it was observed that statistically significant differences existed between the cases and controls in terms of local etiological agent of plaque and periodontal part of CPI index. Conclusion: Provision of better oral health services and education should be made more accessible to the public, as this may help reduce the total morbidity and mortality load of many systemic diseases like CADs.