IADR Abstract Archives

DIAGNOSTIC AND PROGNOSTIC ROLE OF STEM CELL BIOMARKERS IN ORAL SQUAMOUS CELL CARCINOMA; A SYSTEMATIC REVIEW

Objectives: To evaluate the role of cancer stem cell biomarkers in the diagnosis and prognosis of OSCC patients.
Methods: The search strategy was entered into PubMed NLM, EBSCO CINAHL, EBSCO Dentistry & Oral Sciences Source, Wiley Cochrane Library, and Scopus. The full-text eligible studies (n=7) were assessed for their quality using the JBI Critical Appraisal Checklist to evaluate the methodological quality of the studies based on the possibility of bias in their design, conduct, and analysis. Selected studies were further analyzed based on parameters such as publication year, sample size, and outcomes.
Results: A total of 432 studies were identified through the search strategy. A total of 306 records were removed before screening either because of duplication or marked ineligible by the automation tools. Of the screened records 126 out of 104 were removed as they were not conducted on OSCC. Twenty-two reports were sought for retrieval, however, we could not find the full text of 3 studies, and 12 studies were excluded because the biomarkers were not associated with cancer stem cells. The most common cancer stem cell biomarkers associated with OSCC were MCT1, VEGF-A, GD15, HIF1 α, Ki67, Hsp 70, Cyclin D1, and CD44.
Conclusions: Various stem cell biomarkers have been found to have a diagnostic and prognostic role in oral squamous cell carcinoma such as Cyclin D1, VEGF-A, GD15, and CD44. They can be used to predict the overall survival rate, local progression-free survival rate, and distant metastasis-free survival rate in Head and Neck cancer patients.

2023 Pakistan Section Meeting (Hybrid/Lahore, Pakistan)
Hybrid/Lahore, Pakistan
2023

Oral and Maxillofacial Surgery
  • Ali, Faiza  ( AGA KHAN UNIVERSITY HOSPITAL , Karachi , Sindh , Pakistan )
  • Siddiqui, Tania  ( FOUNDATION UNIVERSITY , Islamabad , Pakistan )
  • Sukhia, Rashna  ( AGA KHAN UNIVERSITY HOSPITAL , Karachi , Sindh , Pakistan )
  • Maqsood, Ayesha  ( FOUNDATION UNIVERSITY , Islamabad , Pakistan )
  • Ghandhi, Dinaz  ( AGA KHAN UNIVERSITY HOSPITAL , Karachi , Sindh , Pakistan )
    • NONE
    Poster Session
    Poster Presentations
    Characteristics and outcomes of selected studies
    Author YearParticipantsStudy designCancer Cell BiomarkerOutcomes  
    Srivastava V K et al. 2014112Case-controlVEGF-A Higher in advanced stages (III-IV) of the disease with lymph node involvement  
    Stangl S et al.201877Retrospective Hsp 70High values had poor prognosis for survival  
    Zhong et al. 2013232Prospective open-label, randomized phase III trialCyclin D1Low levels indicate better overall, progression and disease free, loco-regional and distant metastasis- free survival
    High cyclin D1 in patients with cN2 patients are better candidates for induction therapy
    		  
    Yang et al2014230Prospective randomized Phase- III trialGDF- 15Low levels indicate better overall survival and distant metastasis –free survival
    cN+ patient with low GDF-15 and cN- patients with high GDF-15 are better candidates for induction therapy
    		  
    Dejaco D et al 2019123Retrospective StudyEGFR, Ki67, CD44Positive correlation with the primary tumor-specific growth rate  
    Leu M et al 202182Retrospective CohortMCT1High levels indicate poor response to radio- chemotherapy   
    Patel et al 2020404Randomized phase III trialHIF1αLow levels are associated with better progression free survival and overall survival to treatment   

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