IADR Abstract Archives
Irisin protein expression as a potential biomarker for periodontitis: A pilot study
Objectives: To evaluate the changes in the level of irisin protein expression in periodontitis patients as a potential biomarker for periodontitis.
Methods: This study was conducted at Sharif Medical and Dental College, Lahore (SMDC). The subjects were divided into two groups, where each group had 20 patients. Group I comprised patients without periodontitis and was considered a control group. Group II had patients with periodontitis. Periodontitis was assessed based on the community periodontal index (CPI) criteria. About 5 ml of unstimulated whole saliva was collected. The irisin protein was quantified using an enzyme-linked immunosorbent assay (ELISA). Data were analyzed using SPSS version 25, where an independent sample t-test was used to compute the differences in irisin levels between the two groups.
Results: The mean salivary irisin level in the experimental group was lower (7.77±3.1 ng/ml) compared to controls (9.91±3.56 ng/ml). The difference was marginally significant (p=0.051).
Conclusions: Salivary irisin levels are slightly decreased in patients with periodontitis compared to the controls. This study opens a new concept that can lead to more research on the therapeutic effects of irisin on inflammation.
Methods: This study was conducted at Sharif Medical and Dental College, Lahore (SMDC). The subjects were divided into two groups, where each group had 20 patients. Group I comprised patients without periodontitis and was considered a control group. Group II had patients with periodontitis. Periodontitis was assessed based on the community periodontal index (CPI) criteria. About 5 ml of unstimulated whole saliva was collected. The irisin protein was quantified using an enzyme-linked immunosorbent assay (ELISA). Data were analyzed using SPSS version 25, where an independent sample t-test was used to compute the differences in irisin levels between the two groups.
Results: The mean salivary irisin level in the experimental group was lower (7.77±3.1 ng/ml) compared to controls (9.91±3.56 ng/ml). The difference was marginally significant (p=0.051).
Conclusions: Salivary irisin levels are slightly decreased in patients with periodontitis compared to the controls. This study opens a new concept that can lead to more research on the therapeutic effects of irisin on inflammation.