IADR Abstract Archives
Synthesis of Novel Phosphate based Bioactive Glasses for Tissue Regeneration
Objectives: The bioactive glasses are used to regenerate damaged hard tissue and act as bone graft material to increase bioactivity. Their bioactivity depends on characteristics such as chemical composition, topography, porosity and grain size. The aim of this study was to synthesize the novel phosphate based bioactive glass (PBG) at ambient temperature with better solubility and quick resorption rate. The PBG are based on the P2O5 glass-forming network in which calcium oxide and sodium oxide act as network modifiers. The constituent ions of phosphate glasses present in the organic mineral phase of bone; therefore, these glasses have a chemical affinity with bone.
Methods: Sol-gel Evaporation Induced Self-Assembly (EISA) method was used to synthesize the PBG at ambient temperature. The phosphate precursor dissolved in solvent and mixed with calcium and sodium precursors. The solution was aged in a vacuum dessicator and calcined at 600 °C for 6h. The solubility of these glasses was tailored by changing the glass composition. The phase purity, structural, physical investigation of obtained powder was carried out by XRD, FTIR and SEM respectively.
Results: The structural and functional group analysis of prepared bioactive glass was done by FTIR, XRD and SEM. FTIR spectra of PBG, confirmed the crystallinity and exhibited asymmetrical and symmetrical stretching peaks of phosphate at 910 cm-1 and 1125 cm-1 respectively and after the calcination the OH peak disappeared. The XRD pattern of phosphate based bioactive showed the amorphous structure. SEM micrographs showed that fine dense nanoparticles size ranged from (350-450 nm) were formed.
Conclusions: This study shows simple synthetic approach with ability to optimize the degradation and solubility of PBG making them clinically useful for promoting regeneration. Furthermore, phosphate glasses are produced at relatively low temperatures, thus allowing incorporation of drugs and bioactive macromolecules, which can have potent modulating effects.
Methods: Sol-gel Evaporation Induced Self-Assembly (EISA) method was used to synthesize the PBG at ambient temperature. The phosphate precursor dissolved in solvent and mixed with calcium and sodium precursors. The solution was aged in a vacuum dessicator and calcined at 600 °C for 6h. The solubility of these glasses was tailored by changing the glass composition. The phase purity, structural, physical investigation of obtained powder was carried out by XRD, FTIR and SEM respectively.
Results: The structural and functional group analysis of prepared bioactive glass was done by FTIR, XRD and SEM. FTIR spectra of PBG, confirmed the crystallinity and exhibited asymmetrical and symmetrical stretching peaks of phosphate at 910 cm-1 and 1125 cm-1 respectively and after the calcination the OH peak disappeared. The XRD pattern of phosphate based bioactive showed the amorphous structure. SEM micrographs showed that fine dense nanoparticles size ranged from (350-450 nm) were formed.
Conclusions: This study shows simple synthetic approach with ability to optimize the degradation and solubility of PBG making them clinically useful for promoting regeneration. Furthermore, phosphate glasses are produced at relatively low temperatures, thus allowing incorporation of drugs and bioactive macromolecules, which can have potent modulating effects.
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