IADR Abstract Archives
Synthesis And Characterization Of A Smart Injectable Fluoride-Doped Bioactive Glass Material
Objectives: The objective of this study was to develop a polymeric based fluoride doped injectable bioactive glass hydrogel which can be placed directly for dentinal occlusion
Methods: The injectable hydrogel was synthesized by covalent crosslinking method using fluoride doped bioactive glass Co-polymer and crosslinking agent The solution of the copolymer was prepared at 4o C where, 5% fluoride-doped bioactive glass was added, thereafter crosslinking agent was added and stirred until the mixture was homogenous and pH was maintained at 7.4. The hydrogel was characterized by Fourier Transform Infra-Red Spectrometer (FTIR), X-Ray Diffraction (XRD) and Scanning electron microscope-Energy dispersive X-ray detector (SEM) Thermogravimetric Analysis (TGA) and Differential Scanning Calorimetric (DSC) analysis. Setting time and flowability was also analysed. Statistical analysis was performed by One Way ANOVA post hoc tukey’s using SPSS version 22.
Results: FTIR showed broad peak of Si-O-Si at 1290cm-1 and P-O bond appeared at 1026cm-1. The band around 2971cm-1 and 2887cm-1 attributed to the co-polymer. SEM showed agglomerates with rounded particles in the range of 1.2-1.6µm. XRD showed the presence of two phases calcium silicon fluoride with 2θ values at 23.20° (d-spacing 3.83 A°), and calcium silicate with 2θ values at 33.027° (d-spacing 2.71 A°). TGA/DSC graph showed the glass transition temperature of the hydrogel at 520oC. The bioactive glass hydrogel self-hardened when placed at room temperature and at 37oC, the mean initial and final setting time of the bioactive glass hydrogel was 16±1min and 32±1 minutes respectively. The injectability coefficient remained around ≥70% in needle gauge size 21 and 22 and was reduced to 57% in size 23 needle..
Conclusions: The fluoride-doped injectable hydrogel can be deposited easily in tooth cavity and in irregular bone cavities with acceptable setting time and flowability
Methods: The injectable hydrogel was synthesized by covalent crosslinking method using fluoride doped bioactive glass Co-polymer and crosslinking agent The solution of the copolymer was prepared at 4o C where, 5% fluoride-doped bioactive glass was added, thereafter crosslinking agent was added and stirred until the mixture was homogenous and pH was maintained at 7.4. The hydrogel was characterized by Fourier Transform Infra-Red Spectrometer (FTIR), X-Ray Diffraction (XRD) and Scanning electron microscope-Energy dispersive X-ray detector (SEM) Thermogravimetric Analysis (TGA) and Differential Scanning Calorimetric (DSC) analysis. Setting time and flowability was also analysed. Statistical analysis was performed by One Way ANOVA post hoc tukey’s using SPSS version 22.
Results: FTIR showed broad peak of Si-O-Si at 1290cm-1 and P-O bond appeared at 1026cm-1. The band around 2971cm-1 and 2887cm-1 attributed to the co-polymer. SEM showed agglomerates with rounded particles in the range of 1.2-1.6µm. XRD showed the presence of two phases calcium silicon fluoride with 2θ values at 23.20° (d-spacing 3.83 A°), and calcium silicate with 2θ values at 33.027° (d-spacing 2.71 A°). TGA/DSC graph showed the glass transition temperature of the hydrogel at 520oC. The bioactive glass hydrogel self-hardened when placed at room temperature and at 37oC, the mean initial and final setting time of the bioactive glass hydrogel was 16±1min and 32±1 minutes respectively. The injectability coefficient remained around ≥70% in needle gauge size 21 and 22 and was reduced to 57% in size 23 needle..
Conclusions: The fluoride-doped injectable hydrogel can be deposited easily in tooth cavity and in irregular bone cavities with acceptable setting time and flowability