ASSOCIATION BETWEEN TYPE II DIABETES MELLITUS AND THE ENDODONTIC PATHOLOGY EVOLUTION: A SYSTEMATIC REVIEW

Objectives: To identify the relationship of type II DM with the evolution of the pulpal and periapical pathology progression.
Methods: A systematic search was made in MEDLINE / PubMed, ISI Web of Science and Scopus using the following Mesh and key words: diabetes mellitus type 2 OR diabetic patient type 2 OR oxidative stress of glucose OR hyperglycemia; periapical condition AND periapical index OR apical periodontitis OR periapical inflammation; dental pulp OR condition of the dental pulp OR dental pulp cells AND human beings.
Results: 10 studies divided into A) Transversal (n = 8) and B) Longitudinal (n = 2) were selected( Two longitudinal studies with one year follow-up, comparing the success of primary root canal treatment between type 2 diabetic patients and non-diabetics patients , and the remaining eight, were cross-sectional studies, which their total sample number, gather data from 843 patients, 463 diabetics and 369 controls ). The publication period of the 10 studies was from 2001 to 28/02/ 2018. Analysis of the articles suggest that diabetic patients have a higher prevalence of pulpal or periapical pathologies than controls.
Conclusions: There is a biological basis to suggest that type 2 DM can affect the pulpal and periapical immune response affecting the endodontic pathology evolution.