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IADR Abstract Archives

Continentalic Acid from Aralia continentalis shows Activity against MRSA

Objectives: In a continuing search for compound with antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA), chloroform extract of roots of Aralia continentalis was found to contain continentalic acid (CA, C20H30O2), diterpenic acid.

Methods: Continentalic Acid from Aralia continentalis exhibited potent activity against standard methicillin-sensitive Staphylococcu aureus (MSSA) as well as clinical isolates of methicillin-resistant Staphylococcus aureus (MRSA).

Results: It was determined that the continentalic acid had minimum inhibitory concentrations (MICs) of approximately 8-16 µg/ml against S. aureus, including the MSSA and MRSA standard strains.

Conclusions: The results obtained in this study suggest that continentalic acid might have the potential to be adjunct in the treatment of antibiotic-resistant bacteria.


Division: Korean Division Meeting
Meeting: 2005 Korean Division Meeting (Seoul, Republic of Korea)
Location: Seoul, Republic of Korea
Year: 2005
Final Presentation ID:
Abstract Category|Abstract Category(s): Scientific Groups
Authors
  • Kim, Kang Ju  ( Wonkwang University, Iksan, N/A, South Korea )
  • Jeong, Seung Il  ( Mokwon University, Daejeon city, N/A, South Korea )
  • Han, Wan Soo  ( Mokwon Univerisity, Daejeon city, N/A, South Korea )
  • Yun, Yeon Hee  ( Wonkwang University, Iksan, N/A, South Korea )
    • SESSION INFORMATION
    Microbiology / Immunology and Infection Control