Orthodontic
treatment to patient with cleft lip and / or palate is always facing very
difficult problems with the scar tissue during palatal expansion and retention
processes. The scar tissue found after surgical closure of cleft lip and / or
palate has a completely different biological character comparing with a normal
oral mucus tissue. The purpose of our study is to analyze the biological
characteristics of the scar tissue and to test a possibility to modulate scar
tissue development process. As the experimental animal, rabbits(Japanese white)
and rats(S.D.)are used. A histological examination, collagen cross-link
analysis, bio-synthesis of prostaglandin after drug stimulation and
morphological and functional modulation of scar fibroblast are investigated.
The results show a possibility to modulate scar formation process in vitro.