HPV infection in the oral warts from HIV-positive patients

Objectives:To detect the p53 and ki-67 protein ,Human Papilloma Virus (HPV),cytomegalovirus(CMV) and Epstein-Barr virus(EBV)in the warts of oral mucosa from HIV-positive patients , and determine if these oral warts show a profile of p53 and ki-67protein expression suggestive of true dysplasia by comparing to convential dysplastic lesions and oral suquamous cell carcinoma lesions from non-HIV individuals. Methods:The expression p53 and ki-67 protein ,HPV,EBV and CMV were carried out by immunohistochemistry and PCR in 34 cases of oral mucosa warts from HIV-positve patients ,33 cases of oral epithelia dysplasia and 45 cases of oral squamous cell carcinoma. Results:(1)The expression of p53 and ki-67 protein in the cases of oral mucosa warts from HIV-positive patients were respectively 23%and 76%,lower than the oral suquamous cell carcinoma lesions from non-HIV individuals(p<0.05),but no difference with dysplastic lesions from non-HIV individuals(p>0.05).(2)The HPV infection in the warts of oral mucisa from HIV-positive patients is 88.2%,much higher than oral suquamous cell carcinoma lesions and dysplastic lesions from non-HIV individuals(p<0.01).The EBV and CMV infection have not been detected . Conclusions: Most lesions of oral warts from HIV-positive patients are associated with the infection of HPV and show cell proliferation ,some show the mutation of p53.