IADR Abstract Archives
Association of Helicobacter pylori in the Oral Cavity with Overweight
Objectives: The Helicobacter pylori bacterium was originally classified into the Campylobacter genus and is a major periodontopathic bacterial species. In addition, H. pylori DNA has been found in human oral cavity specimens. Several studies have shown an association of periodontal bacteria with elevated body-mass index (BMI >25 kg/m2), whereas no relationship between H. pylori in the oral cavity and BMI has been demonstrated. We analyzed the relationship between H. pylori in the oral cavity and systemic conditions, including overweight.
Methods: The study protocol was approved by the Ethics Committee of Osaka University Graduate School of Dentistry. Saliva specimens and extracted teeth were obtained from 87 patients referred to the Department of Oral and Maxillofacial Surgery II of Osaka University Dental Hospital from March 2016 to June 2017 due to problems requiring tooth extraction. The distribution of H. pylori in all specimens was analyzed using a polymerase chain reaction method. Dental caries status in each subject was evaluated by the same dentist following visual inspection and findings obtained with panoramic photography. Additionally, patient height, weight, and medical history, as well as prior incidence of H. pylori infection in gastric tissue were noted.
Results: Subjects with overweight (BMI >25 kg/m2) exhibited significantly higher detection rates of H. pylori in saliva as compared to non-overweight subjects (P<0.05). A clinical history of digestive disease was not associated with a high rate of H. pylori detection in overweight subjects, whereas overweight subjects with severe dental caries showed a higher detection rate of H. pylori in saliva specimens as compared with the other groups.
Conclusions: These results suggest that H. pylori in the oral cavity is associated with overweight. Additionally, elevated BMI was predominant among subjects with severe dental caries. This study was supported by a JSPS KAKENHI grant (18K17252).
Methods: The study protocol was approved by the Ethics Committee of Osaka University Graduate School of Dentistry. Saliva specimens and extracted teeth were obtained from 87 patients referred to the Department of Oral and Maxillofacial Surgery II of Osaka University Dental Hospital from March 2016 to June 2017 due to problems requiring tooth extraction. The distribution of H. pylori in all specimens was analyzed using a polymerase chain reaction method. Dental caries status in each subject was evaluated by the same dentist following visual inspection and findings obtained with panoramic photography. Additionally, patient height, weight, and medical history, as well as prior incidence of H. pylori infection in gastric tissue were noted.
Results: Subjects with overweight (BMI >25 kg/m2) exhibited significantly higher detection rates of H. pylori in saliva as compared to non-overweight subjects (P<0.05). A clinical history of digestive disease was not associated with a high rate of H. pylori detection in overweight subjects, whereas overweight subjects with severe dental caries showed a higher detection rate of H. pylori in saliva specimens as compared with the other groups.
Conclusions: These results suggest that H. pylori in the oral cavity is associated with overweight. Additionally, elevated BMI was predominant among subjects with severe dental caries. This study was supported by a JSPS KAKENHI grant (18K17252).