IADR Abstract Archives
Bone Regeneration Using a Resorbable Magnesium-Based Membrane in Rabbits Calvaria
Objectives: to examine the performance of the magnesium-based membranes as a barrier membrane for GBR in rabbit calvaria model.
Methods: Ten female New Zealand white rabbits at 21–23 weeks of age and weighing 3–3.5 kg will be used. In each rabbit’s calvarium, four 8 mm defects will be surgically created, they will be randomly filled with blood clot or deproteinized bovine bone mineral (DBBM) bone graft, two defects (one blood clot and one DBBM) will be covered with the magnesium membrane. After 8 weeks, the animals will be euthanized and the specimens will be analyzed using micro-CT and non-decalcified histology. The bone contour and the bone gain will be evaluated
Results: primary results: None of the animals suffered from postoperative infection, a swelling was detected in the soft tissue in the surgical area of the calvaria, this swelling was not accompanied by signs of local or systematic inflammation, Our assumption is that the membrane degradation cause to accumulation of hydrogen gas in the soft tissue
Conclusions: still in the result analysis in this stage
Methods: Ten female New Zealand white rabbits at 21–23 weeks of age and weighing 3–3.5 kg will be used. In each rabbit’s calvarium, four 8 mm defects will be surgically created, they will be randomly filled with blood clot or deproteinized bovine bone mineral (DBBM) bone graft, two defects (one blood clot and one DBBM) will be covered with the magnesium membrane. After 8 weeks, the animals will be euthanized and the specimens will be analyzed using micro-CT and non-decalcified histology. The bone contour and the bone gain will be evaluated
Results: primary results: None of the animals suffered from postoperative infection, a swelling was detected in the soft tissue in the surgical area of the calvaria, this swelling was not accompanied by signs of local or systematic inflammation, Our assumption is that the membrane degradation cause to accumulation of hydrogen gas in the soft tissue
Conclusions: still in the result analysis in this stage