IADR Abstract Archives

A Single Application of Chlorhexidine gel Reduces Gingival Inflammation and IL1-β Following one Stage Implant Placement

Objectives: The biological width around implants is established during the process of wound healing that occurs following implant installation. The study aim was to evaluate the effect of a single application of chlorhexidine (CHX) gel inside the dental implant internal hexagon on peri-implant tissue.
Methods: Forty patients were recruited to this randomized, double-blinded, clinical trial. At the time of implant installation, a 4 mm healing abutment was connected to the implant. In the Test group, chlorhexidine gel 1% was applied inside the implant hex, whereas Control implants did not receive any gel. Clinical and radiographic measurements included soft tissue recession (REC), plaque index (PI), gingival index (GI), keratinized mucosa width (KM), probing depth (PD), and a peri-apical parallel x-ray were performed. Peri-implant crevicular fluid (PICF) was collected for cytokine analysis. Paired t-test was used to compare changes from baseline to 3 months. Man Whitney U test was used to compare Test and Control groups.
Results: Twenty patients in the Test group and 17 in the Control group completed the study. One implant in the Control group failed to ossteointegrate. There were no significant differences between the Control and Test groups for REC changes, bone loss, and PD. GI was significantly lower in the Test group after 1 week (1.76±0.15 vs. 0.78±0.15, respectively) and 3 months (1.09±0.15 vs. 0.23±0.1, respectively). At three months, interleukin 1-β (IL1-β) was higher in the Control group (p<0.04) and a positive correlation was found between GI and IL1-β (rs=0.60424, p=0.00032).
Conclusions: Application of chlorhexidine gel did not alter the peri-implant bone modeling, but reduced inflammation and IL1-β levels in the peri-implant soft tissue.

2021 Israeli Division Meeting (Jerusalem, Israel)

2021

  • Asbi, Thabet  ( Rambam Health Care Campus , Haifa , Haifa , Israel )
  • Abu-hussein, Hiba  ( Rambam Health Care Campus , Haifa , Haifa , Israel )
  • Horwitz, Jacob  ( Rambam Health Care Campus , Haifa , Haifa , Israel )
  • Gabay, Eran  ( Rambam Health Care Campus , Haifa , Haifa , Israel )
  • Machtei, Eli  ( Rambam Health Care Campus , Haifa , Haifa , Israel )
  • Zigdon Giladi, Hadar  ( Rambam Health Care Campus , Haifa , Haifa , Israel )
  • NONE
    Oral Session
    Oral Session 2