Purpose: To assess the clinical and radiographic outcomes of pulpotomies in primary molars performed by application of FS and MTA, when one package of MTA was used for multiple treatments. Methods: Sixty nine children with 86 vital carious primary molars were treated by pulpotomy. Pulpotomy was performed by application of ferric sulfate (FS) in combination with grey or white MTA. One package of MTA was used for 7-8 treatments. The crowns were restored by pre-formed crown. Clinical and radiographic evaluation was performed before and 6 to 47 months after treatment. Results: Radiographic success rates after 12, 24, 36 and 48 months were 93%, 91.4%, 88.8% and 100%, respectively. Seven teeth showed pathologic signs. No statistical differences in success rates were found between white MTA (60-teeth) and grey MTA (16 teeth) groups (p>0.05) or between first primary molars (43-teeth) and second primary molars (33-teeth) (p>0.05). In contrast, maxillary molars showed statistical higher radiographic success rate as compared to mandibular primary molars (95.2% ,92.3% after 12, 30 months, respectively vs. 85.7%, 83.3% after 12, 30 months, respectively, p<0.05). Survival Rate Plot showed 0.9 rate of success after 36 months. Conclusions: Usage of one package of MTA for treatment of multiple pulpotomies in combination with FS did not decrease the success rate as compared to MTA alone from one package for a treatment, with regard to previously published data.