Methods: Both Granisetron and placebo were administered intravenously to 25 healthy volunteers on two different appointments. Gagging levels were recorded before and after administration, as were BP, pulse and O2 saturation. The recorded results were analyzed using tests for non-parametric values (P=0.05).
Results: There was a significant increase of the depth of swab insertion after the administration of both the placebo and the drug. The increase post insertion of the drug correlated with decrease in body mass. There was no significant change in volunteers heart rate, blood pressure and O2 saturation, and no adverse effects were reported.
Conclusion: It is possible that relaxation caused a decrease in gagging, and some placebo effect was noticed as well. Only the drug effect increased proportionally to the increase of drug dosage per kilogram of body mass. Increased dosage of Granisetron may have a better effect on gagging patients. The true efficacy of Granisetron in this treatment protocol is yet to be fully established.