Our clinical evaluation demonstrated the retention rate and pulpal response of the self-etching adhesive system, Clearfil Liner Bond 2 was excellent at 10-years. Most cases showed slight marginal changes during clinical function, however, these changes were not clinically severe by USPHS criteria. Consequently, these clinical conditions did not require replacement since no recurrent caries were present. These data demonstrate that placement of the Clearfil Liner Bond 2 self-etching adhesive system is acceptable for clinical restoration of human teeth following 10-years of clinical function.