New Technologies for the Treatment of Oral Malodour

Methods: Thirty-four subjects participated in this blinded, crossover study. After a wash-out period prior to each session of product use, subjects reported to the site having abstained from oral hygiene, eating and drinking from 10pm the evening prior to treatment visits. The subjects brushed with their weighed dose of assigned paste and were asked to expectorate their toothpaste slurry into a collection vessel at 30 and 60 seconds during the supervised brush time. The expectorant foam was measured immediately, after which, subjects were provided with 10 ml of sterile water to rinse and expectorate into the same vessel. The samples were transported to the laboratory for analysis. Bacteria (total anaerobes and VSC-producing bacteria) were enumerated using appropriate selective media. To calculate the amount of debris, a measured portion of the sample was deposited onto a pre-weighed dish and weighed. These dishes were dried thoroughly and weighed after cooling.

Results: There were highly statistically significant differences in foam volume generation for the gel-to-foam dentifrice with 105% greater foam volume generation. Further, the gel-to-foam dentifrice removed 15.77% more debris than the commercially-available dentifrice (p-value=0.0342). There was greater removal of total anaerobes and VSC-producing bacteria by the gel-to-foam dentifrice versus the commercially-available dentifrice (p-value<0.0001).

Conclusion: After use of the gel-to-foam dentifrice or a commercially-available dentifrice, the results of this study demonstrate the gel-to-foam dentifrice removes a greater amount of oral debris during brushing and removes more bacteria associated with oral malodour.