Objectives: One of the most common types of failure in removable dentures is the bond failure between the synthetic polymer teeth and the acrylic resin denture-base material. The purpose of this study was to compare the bond quality of four different denture base materials with a synthetic polymer type of teeth. Methods: For the purpose of the present study four acrylic resin denture-base materials were used, namely: two fast heat-cured acrylic resin denture-base materials, Stellon QC-20/Dentsply and Weit-on/Rapid (groups A and B), one auto-curing, Castdon/Dreve (group C) and one high-impact heat-cured acrylic resin, Lucitone 199/Dentsply (group D). One type of acrylic resin teeth (Cosmo HXL/Dentsply) was bonded to the above mentioned materials according to the manufacturer's instructions. Specimens were prepared containing 6 upper anterior teeth for every base material. The specimens were tested for shear bond strength in a universal testing machine (Testometer 10, Monsanto, USA) at a crosshead speed of 5 mm / min. Fractures were observed visually and in an optical microscope (Eclipse 200, Nikon, Japan) in magnification 10x and mode of failure classified as adhesive and cohesive according to the ISO 3336/1993. Results: All the specimens presented a cohesive mode of failure. In groups A and D, 5 of the specimens were fractured in the synthetic polymer tooth part and 1 in the base material part. In groups B and C, 4 of them were fractured in tooth part and 2 in the base material part. Conclusion: According to the results the bond quality in all tested groups was successful, meeting completely the ISO 3336 specification.