High fluoride toothpastes enhance remineralization of deep enamel lesions

Aim: This study addressed the dose response of toothpastes in the concentration range 0-5000 ppmF, as well as the fluoride salt type, on de- and remineralization of ‘deep' (150 µm) enamel lesions. Although clinical studies have shown increased efficacy of toothpastes with elevated fluoride content, little is known about the mechanistic explanation, nor how that is affected by fluoride type. Methods: pH-cycling of enamel lesions with 5 min F-treatments (using 30%w/v dilutions) daily. Lesion mineral uptake and loss assessed from solution concentration changes and microradiography. Results: 5000 ppm fluoride product treatments resulted in enhanced remineralization and inhibited demineralization both significantly different from the placebo, 500 and 1500 ppmF paste data. Significant differences between NaF and AmineF (tested as Nicomethanol fluorhydrate) were observed in favor of AmineF. Conclusion: The re-/demineralization balance of deep lesions benefits from the use of high fluoride toothpastes.

Supported by Pierre Fabre Oral Care, France