Inflammatory cellular responses to White and Gray Mineral Trioxide Aggregate

Objectives: The aim of this investigation was to compare the biocompatibility of white and gray Mineral trioxide aggregate in subcutaneous connective tissue of rats. Methods: 40 Wister rats were used in this study. Polyethylene tubes filled with gray or white MTA and empty ones as control group implanted into subcutaneous tissue and harvested after 7, 15, 30, 60 and 90 days intervals. Section of 5 -µm were stained with hematoxylin eosin and observed under a light microscope. Inflammatory reactions were categorized as 0, none (without inflammatory cells), 1, weak (inflammatory cells < 25), 2, moderate (25 to 125 inflammatory cells), 3, severe (more than 125 inflammatory cells).Statistical analysis was performed with Kruskal-Wallis test. Results: Both kind of MTA provoked severe inflammatory reaction after 7 days that significantly differ from control group (p<0.05).However, there are no significant differences between white and gray MTA and control group at 15, 30, 60 and 90 days (p>0.05). Conclusions: Both kinds of MTA had similar inflammatory cellular response.