Down's syndrome is caused by trisomy of the 21st chromosome and presents well known problems in the dental office, because of its multiorgan involvement. Most of the affected subjects present some degree of mental retardation, and malformation of head and neck. Among the more affected organs is the oral cavity, including tongue (macroglosia), dental abnormalities in number and shape and poor bone quality (osteoporotic-like) of jaw and alveolar ridge. Poor cooperation in the dental office is also a factor that should be taken into consideration when treatment plan is prepared. Until now, Down's syndrome patients were not considered good candidates for rehabilitation by dental implants because of the problems mentioned and the socio-economic status of many of them. We present here, for the first time, a case oral rehabilitation of a 16 Y.O. Down's syndrome subject by dental implants, done in multiple sessions under general anesthesia. A review of the problems and the implants type and procedures are discussed. We believe that more experience is needed and more cases should be performed before we can say that this method of oral rehabilitation is suited for Down's syndrome subjects, but this case is a promising beginning.