IADR Abstract Archives
The Prevalence of Developmental Defects of Enamel in a Cohort of Adults with Cystic Fibrosis
Objectives: It is fair to assume that oral health in people with cystic fibrosis (PwCF) may be affected considering the disease is a multisystem condition and is treated by an array of pharmacological therapies. Previous studies reported an increased prevalence of enamel defects in CF populations, however most of these studies involved children ≤18 years. The aim of this study was to determine if the prevalence of developmental was higher in a cohort of adults with CF.
Methods: This cross-sectional study was given full ethical approval by the Clinical Ethics Committee of the Cork Teaching Hospitals (ECM 03/2022 PUB). A study group (n=92) and a control group (n=92) were recruited. Adults aged ≥18 years with CF were included in the study group. The control group comprised of healthy adults aged ≥18 years. Participants completed the WHO Oral Health Questionnaire for adults with additional questions for PwCF. A dental examination was performed by two calibrated dentists. Defects were recorded using the DDE index. Statistical analysis was conducted.
Results: 64% (n=59) of study participants experienced at least one defect compared to 30%(n=28) of controls. Multivariate analysis revealed a significant difference in defect prevalence according to CF status (p =<0.001) but no difference according to gender (p=0.8011). Demarcated opacities(n=164) were the most prevalent defect in the study group, followed by diffuse opacities(n=74), hypoplastic defects(n=45).
Conclusions: This study revealed a significant difference in the prevalence of dde in PwCF compared to people without CF. Enamel defects may place PwCF at a higher risk of caries, erosion, and poor aesthetics. These defects may be a consequence of genetic mutations, disease specific effects, or pharmacological therapies used to treat the disease. Identifying populations at a greater risk of oral disease is important as this information may form the foundation for public health policy.
Methods: This cross-sectional study was given full ethical approval by the Clinical Ethics Committee of the Cork Teaching Hospitals (ECM 03/2022 PUB). A study group (n=92) and a control group (n=92) were recruited. Adults aged ≥18 years with CF were included in the study group. The control group comprised of healthy adults aged ≥18 years. Participants completed the WHO Oral Health Questionnaire for adults with additional questions for PwCF. A dental examination was performed by two calibrated dentists. Defects were recorded using the DDE index. Statistical analysis was conducted.
Results: 64% (n=59) of study participants experienced at least one defect compared to 30%(n=28) of controls. Multivariate analysis revealed a significant difference in defect prevalence according to CF status (p =<0.001) but no difference according to gender (p=0.8011). Demarcated opacities(n=164) were the most prevalent defect in the study group, followed by diffuse opacities(n=74), hypoplastic defects(n=45).
Conclusions: This study revealed a significant difference in the prevalence of dde in PwCF compared to people without CF. Enamel defects may place PwCF at a higher risk of caries, erosion, and poor aesthetics. These defects may be a consequence of genetic mutations, disease specific effects, or pharmacological therapies used to treat the disease. Identifying populations at a greater risk of oral disease is important as this information may form the foundation for public health policy.