IADR Abstract Archives

Apical Periodontitis and All-Cause Mortality Among 60-70 Year-Old Men

Objectives: To determine whether apical periodontitis (AP) was predictive of all-cause mortality in a cohort of 60-70 year-old men In Northern Ireland enrolled in the Prospective Epidemiological Study of Myocardial Infarction (PRIME) study.
Methods: The periapical status was assessed from dental orthopantomograms (OPT) using the periapical index (PAI; ├śrstavik et al. 1986). A PAI score of 3-5 was equated with AP. Men with AP were divided into a HIGH (> 25% readable teeth with AP) and a LOW (<25% readable teeth with AP) group. Logistic regression was used to calculate odds ratios (OR).
Results: The average age of the 1361 men at the baseline was 64.2 (SD 2.9) years, and 441 (32.4%) died during 15.4 (SD 4.1) years of follow-up. There were 152 men with HIGH AP related to teeth that had not been root filled and they had on average 3.2 (SD 1.6) such teeth with AP. 69 (45.4%) of these men died compared with 372 (30.8%) of 1208 men in the LOW AP group, Chi-square = 13.13, p=0.0003. The unadjusted OR for a man in the HIGH AP group to have died compared with the LOW group was 1.87 (95% CI 1.33-2.63). The OR attenuated to 1.61 (95% CI 1.11-2.34), p=0.012 after adjustment for age, smoking, body mass index (BMI), Socio-economic status (SES), education status and pattern of dental attendance. The comparable unadjusted OR for root filled teeth was 1.40 (95% CI 0.57-3.46), p=0.46.
Conclusions: The men in this prospective study with high levels of apical periodontitis related to teeth that were not root filled were at an increased risk of death.

2021 Irish Division Meeting (Virtual)


  • Mcclory, Mary  ( School of Medicine Dentistry and Biomedical Sciences Queen's University of Belfast , Belfast , Ireland ;  Queen's University Belfast Wellcome-Wolfson Institute for Experimental Medicine , Belfast , Belfast , United Kingdom )
  • Lundy, Fionnuala  ( Queen's University Belfast , Belfast , Ireland )
  • Winning, Lewis  ( Dublin Dental University Hospital , Dublin , Ireland )
  • Linden, Gerard  ( Queen's University of Belfast , Belfast , Ireland )
  • El Karim, Ikhlas  ( School of Medicine Dentistry and Biomedical Sciences Queen's University of Belfast , Belfast , Ireland )
  • NONE
    HSC R&D office EAT/5383/17
    Oral Session
    Dental Health Foundation Award