IADR Abstract Archives

PLGA Microspheres Containing Minocycline as Drug Delivery System

Objectives: Poly (lactic-co-glycolic acid) (PLGA) has been one of the most used polymers for drug delivery and tissue engineering applications. PLGA is a biodegradable polymer with great potential for pharmaceutical applications due to its favorable properties, such as good biocompatibility, biodegradability, and mechanical strength. Also, it has been approved by the Food and Drug Administration (FDA) for drug delivery system. Among different forms of PLGA-based drug delivery systems, microspheres or microparticles are the most common.

Methods: The microspheres containing Minocycline were prepared by the w/o/w double emulsion solvent evaporation method. Microsphere formulations were morphologically characterized by scanning electron microscope (SEM). Minocycline loaded PLGA microspheres were subjected to an in vitro release test under static conditions.

Results: The SEM images showed that the size of microspheres containing Minocycline was in the range of 10 microns. The in vitro release experiment showed that the release time was over 26 days. The release profile of Minocycline from PLGA microspheres showed a constant and controlled release. Furthermore, the curve showed that there was a burst release on the eighth day.

Conclusions: In conclusion, the biodegradable PLGA microspheres containing Minocycline were successfully prepared by double emulsion solvent evaporation method. Various factors related to the preparation process influenced the drug encapsulation efficiency and the cumulative drug release was subsequently investigated. Ultimately, spherical PLGA microparticles with encapsulation efficiencies higher than 90% and prolonged Minocycline release over 30 days were obtained.

This abstract is based on research that was funded entirely or partially by an outside source: This work was supported financially by a grant (NO:310-3685) from dental school of Shahid Beheshti university of Medical Sciences, Tehran, Iran


Iranian Division Meeting
2013 Iranian Division Meeting (Tehran, Iran)
Tehran, Iran
2013

Scientific Program
  • Karimi Soflou, Reza  ( Department Of biomedical engineering, Science And Research Branch, Islamic Azad University, Tehran, , Iran )
  • Nojehdehyan, Hanieh  ( Department of Dental Materials, School of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, , Iran )
  • Torshabi, Maryam  ( Department of Dental materials, Dental School, Shahid Beheshti University of Medical Sciences, Tehran, , Iran )
  • Tabatabaei, Fahimeh Sadat  ( Dental Material department; Dental School;Shahid Beheshti University of Medical Sciences, Tehran, , Iran )
    • Oral Session
    Oral Medicine and Pharmacology Research
    12/12/2013