Methods: This research was a clinical randomized parallel double blind trial. 20 patients with treatment plan of chemotherapy who met the inclusion criteria entered the study and were randomly divided into the two following groups: Group 1 received routine medication of cancer therapy center, Group 2 used CPP-ACPF (MI paste, GC USA) paste twice a day. The baseline status of oral conditions of patients (mucositis, dry mouth, infection, diminished tasting sense, difficulty in food intake, and burning sensation of mucosa, were recorded and re-evaluated after 21 and 42 days. The data were analyzed with Mann-Whitney U-test.
Results: Mann-Whitney test showed that using CPP-ACPF paste twice daily did not cause any significant difference in oral complication of subject group compared to the control (P>0.05).
Conclusions: Using CPP-ACPF paste before starting chemotherapy and during it, could not significantly improve the oral status of patients undergoing this treatment.