Methods: This study was a randomized double blind clinical trial. Parameters included age, gender, tissue inflammation, degree of pain, and size of the ulcer. After entering the study, patients were randomized into two groups. Both groups had oral biopsy ulcers ranging between one and two centimeters. Patients in the first group were treated by simple mucoadhesive paste, while patients in the second group were treated by phenytoin mucoadhesive paste. Both pastes were applied for 5 days after the biopsy. Statistical analysis was done using Mann-Whitney test.
Results: After the second and third appointments, it was observed that the rate of wound healing and decrease in the size of the ulcers were significantly quicker in the second group (P=0.001 and P=0.003 respectively) and the patients in the second group reported less pain. Diameter of the inflammatory halo was not significantly different between the two groups.
Conclusions: Applying phenytoin mucoadhesive paste on biopsy ulcers resulted in accelerated wound healing and decrease in pain, but had no effect on the diameter of the inflammatory halo.