IADR Abstract Archives

Effects of Ibuprofen, Diphenhydramine and Aluminum Magnesium Simethicone on Aphthous Stomatitis

Objective: Recurrent aphthous stomatitis (RAS) is the most common and painful oral inflammatory lesion with unknown etiology. This study aims to determine the therapeutic effects of ibuprofen, diphenhydramine and aluminum magnesium simethicone (AlMgS) syrup on reducing oral aphthous ulcers pain

Method: 31 patients with RAS participated in this double-blind clinical trial. Subjects were randomly divided in two groups. Control group (n=14) received drug mixture as drug A (diphenhydramine and AlMgS) and case (n=17) received drug B ( ibuprofen, diphenhydramine and AlMgS). Drugs were topically applied on ulcers by the patients 3 times a day for 3 days. Patients were re-examined for the symptoms on the fourth day following their first visits using VAS (Visual Analogue Scale) tool. Statistical analysis was performed using t-test and chi-square test. 

Result: Pain was significantly reduced in both groups (P<0.001) however, the difference in pain decrease among both groups was not statistically significant (P=0.358). Also, no significant difference between two groups was detected regarding the duration of pain or burning sensation (P=0.57). 

Conclusion: The results of this study demonstrate that in comparison with diphenhydramine and AlMgS syrup, the studied mixture did not effectively reduce pain level, duration and burning sensation.

Iranian Division Meeting
2012 Iranian Division Meeting (Tehran, Iran)
Tehran, Iran
2012

Scientific Program
  • Borhan-mojabi, Karayoun  ( Qazvin University of Medical Sciences, Qazvin, N/A, Iran )
  • Mirmiran, Faezeh  ( Qazvin University of Medical Sciences, Qazvin, N/A, Iran )
  • Nassiri-asl, Marjan  ( Qazvin University of Medical Sciences, Qazvin, N/A, Iran )
  • Nazeman, Pantea  ( Qazvin University of Medical Sciences, Qazvin, N/A, Iran )
    • Oral Session
    Pharmacology/Therapeutics/Toxicology
    12/28/2012