Methods: This was a prospective, double blind, randomized, cross-over, placebo-controlled, clinical trial.10 patients with mean 18.6 years acted as their own controls. Each patient underwent bilateral third molar surgery in mandible with interval of 1 week between each operation. When the tooth was removed, on one occasion the socket randomly was filled with 2 pieces of geltamp containing 0.4 ml normal saline or 0.4 ml salmon calcitonin. anyway of poor pain control, patients were allowed to take additional analgesia (ibuprofen 400 mg).patients were asked to record their pain, at intervals, over an 24-hour period on 10 cm visual analog scale. The number of additional analgesia and the time to take it for the first time were recorded by patient. ANOVA with repeated measure and Wilcoxon test were used for statistic analysis
Results: There was no significant difference (p>0.05) between locally applied salmon calcitonin treatment and placebo. there was no significant difference between placebo and calsitonin for the time to uptake of additional analgesia or the number that required it. The local application of casitonin had no adverse effect on homeostasis or healing.
Conclusions: We can concluded from this study that locally application of salmon calcitonin clinically seems to be efficient in control of post-operative pain after third molar surgery, in the event that statistically analysis raveled no difference between salmon calcitonin and placebo. The lack of efficacy of local salmon calcitonin in statistically analysis may in part be related to fast release of calcitonin or because of low number of patients.