Few studies show that C-kit protein which one of immunohistochemical markers is useful for distinguishing between this two lesions.
Objectives: The aim of this study was Evaluation of the accuracy of immunohistochemical marker CD117 in histopathologic differentiation of two salivary tumor adenoid cyctic carcinoma and polymorphous low grade adenocarcinoma .
Methods: In this study ,15 cases of adenoid cystic carcinoma and 5 cases polymorphouse low grade adenocarcinoma prepared and stained in IHC method.
Number of stained neuclei per 1000 neucli of per section ,make the labeling index.(LI)
Labeling index (LI) of each cases was calculated and mean LI of each group achieved. The T-test was used to compare the results.
Results: The mean of LI was 71.20 ± 27.45 percent in adenoid cystic carcinoma (n=15) and 35.37±36.43 percent in polymorphouse low grade adenocarcinoma (n=5) .So PV was 0.031 (P ≤ 0.005) .ROC Curve show that cut off point of this study was 73 (with sensitivity of 80% and specificity of 53%.
Conclusions: According to this study ,staining of neucleus for immunohistochemical marker of C-kit ,is differentiate significantly in adenoid cystic carcinoma and polymorphouse low grade adenocarcinoma .