Efficacy Of PRP In Treatment of Intrabony Defects

Objectives:  Regenerative periodontal therapy with a combination of platelet rich plasma(PRP) + an anorganic bovine bone mineral(ABBM)+guided tissue regeneration(GTR) has been shown to result in significantly higher probing depth reduction and clinical attachment level gains compared to the treatment with open flap debridement(OFD)alone ,ABBM alone and GTR alone. However, there are no data evaluating the efficacy of PRP in combination of connective tissue graft as a membrane and ABBM .The aim of this study is to clinically evaluate the efficacy of  ABBM and GTR by the means of connective tissue as a membrane (CTG)with an without PRP  in treatment of intrabony defects.

Methods: In this double-blind randomized clinical trial 15 pair of intrabony defects in 15 patients with chronic periodontal disease were randomly treated with a combination of either PRP+ABBM+CTG or ABBM+CTG. The following clinical parameters were evaluated at baseline and at 6 months Re-entry with using a stent as reference point: probing pocket depth (PPD), clinical attachment level (PAL-S), free gingival margin position (FGM-S), crestal position(CREST-S),Crest to defect depth and defect depth to stent. Independent t-test for comparing the results between the groups and paired t-test for comparing the results in groups were used for statistical analysis.

Results:  No differences in any of the studied parameters were observed in comparison between baseline and 6months reentry between the groups. Both groups showed no significant differences in the position of free gingival margin comparing to baseline.

Conclusions:  Within the limitation of this study it can be concluded that both treatment modality could be effective in treatment of intrabony defects and PRP had no additive effect in improving the clinical parameters. Also connective tissue graft could have act as a good alternative membrane.