IADR Abstract Archives
Correlation between IGE and Histamin and Pulp Polyp
Background & Aim: Numerous studies have been done on the immunopathogenesis of different
status of dental pulp, but less attention was paid on pulp polyp and hyperplastic pulpitis. Therefore,
the aim of this study was to investigate the relation between presence and concentration of IgE and
histamine of the pulp and pulp polyp.
Materials & Methods: This study was an analytical case control. For this reason, 17 samples of pulps
with polyp and 16 samples of healthy pulps were collected. After 3-days tissue culturing Sandwich
ELISA (Enzyme Linked Immuno-Sorbent Assay) and competitive ELISA were used for
determination of and histamine, respectively. Spearman’s correlation coefficient, and Mann-Whitney
U, Chi-square tests were used for statistical analysis.
Results: In 100% and 50% of polyp pulps and healthy pulps was detected with the mean
concentration of 0.762±0.486 and 0.193± 0.219 IU/ml. Presence of histamine was observed in 100%
and 12.5% of polyp pulps and healthy pulps with the mean concentration of 30.835±34.153 and
3.125±8.732ng/ml, respectively. Statistical analysis demonstrated significant correlation between IgE
concentration and pulp polyp (P=0.000), and also between concentration of histamine and pulp polyp
(P=0.001). There was also a significant statistical correlation between the concentration of IgE and
histamine in two groups (P=0.049)
Conclusion: Probable effect of hypersensitivity type I reaction or allergy on the pathogenesis of
polyp pulp can be suggested.
Key Words: Allergy, Histamine, Hyperplastic pulpitis, IgE, Immunopathogenesis, Pulp polyp
status of dental pulp, but less attention was paid on pulp polyp and hyperplastic pulpitis. Therefore,
the aim of this study was to investigate the relation between presence and concentration of IgE and
histamine of the pulp and pulp polyp.
Materials & Methods: This study was an analytical case control. For this reason, 17 samples of pulps
with polyp and 16 samples of healthy pulps were collected. After 3-days tissue culturing Sandwich
ELISA (Enzyme Linked Immuno-Sorbent Assay) and competitive ELISA were used for
determination of and histamine, respectively. Spearman’s correlation coefficient, and Mann-Whitney
U, Chi-square tests were used for statistical analysis.
Results: In 100% and 50% of polyp pulps and healthy pulps was detected with the mean
concentration of 0.762±0.486 and 0.193± 0.219 IU/ml. Presence of histamine was observed in 100%
and 12.5% of polyp pulps and healthy pulps with the mean concentration of 30.835±34.153 and
3.125±8.732ng/ml, respectively. Statistical analysis demonstrated significant correlation between IgE
concentration and pulp polyp (P=0.000), and also between concentration of histamine and pulp polyp
(P=0.001). There was also a significant statistical correlation between the concentration of IgE and
histamine in two groups (P=0.049)
Conclusion: Probable effect of hypersensitivity type I reaction or allergy on the pathogenesis of
polyp pulp can be suggested.
Key Words: Allergy, Histamine, Hyperplastic pulpitis, IgE, Immunopathogenesis, Pulp polyp