IADR Abstract Archives
Drug-related dysgeusia: A systematic review
Objectives: Dysgeusia is an alteration in taste characterized by unpleasant taste. It can affect the nutritional and psychological status and decrease the quality of life of patients. It may be caused by nerve injury, head and neck trauma or surgery, infections, radiotherapy, and drugs, but certain etiologic factors have not yet been identified. Physicians commonly prescribe medications for patients; therefore, understanding dysgeusia as a drug side effect is important for practitioners. The aim of our study is to provide detailed information about dysgeusia in patients receiving different common medications.
Methods: An electronic search was conducted in MEDLINE, Google Scholar and Scopus databases and studies were selected according to our inclusion criteria. We included studies on human subjects that reported dysgeusia as a drug side effect.
Results: Forty-seven eligible studies were included in our systematic review. The most commonly reported offending drugs were podophyllum resin, docetaxel, vismodegib, cyclophosphamide + doxorubicin, azelastine, JNJ-42756493, paclitaxel + pazopanib, levofloxacin, captopril, BMS-182751, sunitinib, MAP0004, iodide I 131, DFN-02, nortriptyline, loxapine, liftegrast, lansoprazole + amoxicillin + clarithromycin, ciprofloxacin + tinidazole, omeprazole + amoxicillin + clarithromycin, metronidazole + clarithromycin + ranitidine and pivaloyloxymethyl butyrate.
Conclusions: The quality of evidence was low in most reviewed studies. More studies with standard methodology are needed in this field. However, physicians and dental practitioners must consider the probability of dysgeusia as an adverse side effect when prescribing some certain medications.
Methods: An electronic search was conducted in MEDLINE, Google Scholar and Scopus databases and studies were selected according to our inclusion criteria. We included studies on human subjects that reported dysgeusia as a drug side effect.
Results: Forty-seven eligible studies were included in our systematic review. The most commonly reported offending drugs were podophyllum resin, docetaxel, vismodegib, cyclophosphamide + doxorubicin, azelastine, JNJ-42756493, paclitaxel + pazopanib, levofloxacin, captopril, BMS-182751, sunitinib, MAP0004, iodide I 131, DFN-02, nortriptyline, loxapine, liftegrast, lansoprazole + amoxicillin + clarithromycin, ciprofloxacin + tinidazole, omeprazole + amoxicillin + clarithromycin, metronidazole + clarithromycin + ranitidine and pivaloyloxymethyl butyrate.
Conclusions: The quality of evidence was low in most reviewed studies. More studies with standard methodology are needed in this field. However, physicians and dental practitioners must consider the probability of dysgeusia as an adverse side effect when prescribing some certain medications.