IADR Abstract Archives
Anti-inflammatory effect of Enoxolone in human gingiva
Objectives: Gingivitis is the most common form of periodontal diseases. Bacterial plaque is the most important factor in gingivitis. Control of plaque can be done in two ways: mechanical and chemical such as toothbrushes and toothpastes respectively. Enoxolone is a major component of a traditional plant called Licorice. This substance contain some pharmaceutical properties including of both antiviral and antifungal activities. The purpose of this study is to evaluate the anti-inflammatory action of Enoxolone in toothpaste on gingivitis by measuring of plaque, gingival and bleeding indices.
Methods: This was an experimental Randomized control double blind clinical trial. 40 subjects who had gingivitis were selected. The patients were matched according to the plaque, gingival and bleeding indices and then divided into test and control group, randomly. The Oral-B toothbrush was given to all subjects. The toothpaste containing Enoxolone was given to the test group and Crest toothpaste with no Enoxolone was given to the control group. Each group was assigned to brush the teeth, twice a day then massage the gums with pastes and then wash their mouth. After 21 days, three indices were measured again. Changes in indices were statically analyzed according to T-Test, Wilcoxon and Mann-Whitney tests.
Results: The mean of all three indices were decreased significantly in both group after 21 days. (P=0.001) In comparison between 2 groups, there were no significant differences in reduction of plaque index (P=0.143), but gingival and bleeding indices had significantly decreased in test group. (P=0.006 and P=0.017)
Conclusions: within the limit of this study it was shown that Enoxolone has the ability to reduce gingival and bleeding indices; therefore it has an anti-inflammatory effect.
Methods: This was an experimental Randomized control double blind clinical trial. 40 subjects who had gingivitis were selected. The patients were matched according to the plaque, gingival and bleeding indices and then divided into test and control group, randomly. The Oral-B toothbrush was given to all subjects. The toothpaste containing Enoxolone was given to the test group and Crest toothpaste with no Enoxolone was given to the control group. Each group was assigned to brush the teeth, twice a day then massage the gums with pastes and then wash their mouth. After 21 days, three indices were measured again. Changes in indices were statically analyzed according to T-Test, Wilcoxon and Mann-Whitney tests.
Results: The mean of all three indices were decreased significantly in both group after 21 days. (P=0.001) In comparison between 2 groups, there were no significant differences in reduction of plaque index (P=0.143), but gingival and bleeding indices had significantly decreased in test group. (P=0.006 and P=0.017)
Conclusions: within the limit of this study it was shown that Enoxolone has the ability to reduce gingival and bleeding indices; therefore it has an anti-inflammatory effect.